Vagifem is superior to vaginal Premarin in induction of endometrial thickness in the frozen-thawed cycle patients with refractory endometria: A randomized clinical trial

Background: embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. vaginal estrogen, such as vagifem vaginal tablets and premarin vaginal cream, is a regimen used for the patients with refractive endometria. objective: our objective was to compare the effects of vagifem and premarin on the endometrial thickness of the patients with refractive endometria. materials and methods: in this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received vagifem vaginal tablets and 30 women received premarin vaginal cream. endometrial thickness was measured on the 14th day of drug administration. results: comparing the endometrial thicknesses of the two groups showed that the endometria of the vagifem group was significantly thicker than that of the premarin group (5.93±0.38 vs. 6.74±0.32; p < 0.001). conclusion: vagifem is superior to premarin in induction of endometrial thickness in frozen-thawed embryo transfer cycles in the patients with refractive endometria