does dual trigger improve euploidy rate in normoresponder? a cross-sectional study

Background: with the introduction of the dual triggering-gonadotropin-releasing hormone (gnrh) analog and recombinant human chorionic gonadotropin (hcg) combination, women with a history of low mature oocyte proportion and empty follicle syndrome were shown to benefit from the dual trigger.objective: to investigate whether dual triggering of oocyte maturation with a gnrh agonist (gnrha) combined with hcg can affect the euploidy rate and improve in vitro fertilization outcomes for normoresponder women.materials and methods: in this cross-sectional study, 494 women who underwent controlled ovarian stimulation with hcg (n = 274) or dual triggering (hcg+gnrha, n = 220) at acibadem maslak hospital, assisted reproductive unit, from january 2019-2022 were enrolled in this study. preimplantation genetic testing for aneuploidy was performed on all participants. results: both groups had similar baseline and clinical characteristics. of the 881 embryos biopsied, 312 (35.4%) were reported as euploid in the hcg trigger group; in the dual trigger group, 186 (29.8%) of 623 screening embryos were reported as euploid. the hcg group had a higher euploidy rate per biopsied embryo, although the difference was not statistically significant (31.4 ± 26.5 vs. 26.5 ± 33.3, p > 0.05). conclusion: in normoresponders, adding gnrha for final follicular maturation to hcg did not improve the euploidy rate.