circulating serum preptin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis

Background: polycystic ovary syndrome (pcos) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. among the new markers, preptin seems to play a significant role in metabolic disorders.objective: this meta-analysis was conducted to determine the relationship between circulating preptin levels and pcos.materials and methods: a systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as pubmed, web of science, scopus, cochrane, embase, and the google scholar search engine, using a predefined search strategy. a random-effects model was used to combine standard mean difference (smd) and 95% ci to compare results between groups. meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity.results: the meta-analysis encompassed a total of 8 studies and 582 participants. the results indicate a statistically significant association between pcos and serum preptin levels, with a pooled standardized mean difference (smd = 1.35; 95% ci]: 0.63-2.08; p < 0.001). further analysis suggested a significant difference in serum preptin levels between women with pcos and higher homeostatic model assessment for insulin resistance ratio (smd = 2.40; 95% ci: 1.17-3.63; p < 0.001) within the subgroup.conclusion: our meta-analysis shows that increased serum preptin levels are associated with pcos, suggesting that preptin may be related to the pathogenesis of pcos and may be recognized as a novel diagnostic biomarker for pcos. however, further studies are needed to confirm our results.