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The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
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نویسنده
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Salman Suleyman ,Kumbasar Serkan ,Hacimuftuoglu Ahmet ,Ozturk Berna ,Seven Bedri ,Polat Beyzagul ,Gundogdu Cemal ,Demirci Elif ,Yildirim Kadir ,Akcay Fatih ,Uslu Turan ,Tuncel Daloglu Ferrah ,Suleyman Halis
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منبع
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international journal of reproductive biomedicine - 2012 - دوره : 10 - شماره : 4 - صفحه:363 -372
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چکیده
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Background: osteoporosis is a chronic disease characterized by a decrease in bone mineral density (bmd) and corruption of the microarchitectural structure of bone tissue. objective: it was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. materials and methods: bone mineral density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (alp) measurements were performed. obtained results were compared with that of alendronate. results: oophorectomy induced osteoporosis was exacerbated by methylprednisolone. alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. conclusion: combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats.
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کلیدواژه
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Osteoporosis ,Metyrosine ,Methylprednisolon ,Alendronate ,Ovariectomy
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آدرس
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Igdir National Hospital, Department of Obstetrics and Gynecology, Turkey, Igdir National Hospital, Department of Obstetrics and Gynecology, Turkey, Ataturk University, Medical Faculty, Department of Pharmacology, Turkey, Ataturk University, Medical Faculty, Department of Pharmacology, Turkey, Ataturk University, Medical Faculty, Department of Nuclear Medicine, Turkey, Ataturk University, Medical Faculty, Department of Pharmacology, Turkey, Ataturk University, Medical Faculty, Department of Pathology, Turkey, ,Ataturk University, Medical Faculty, Department of Pathology, Turkey, Ataturk University, Medical Faculty, Department of Physical Medicine and Rehabilitation, Turkey, ,Ataturk University, Medical Faculty, Department of Biochemistry, Turkey, Fatih Sultan Mehmet Educationand Research Hospital, Department of Physical Medicine and Rehabilitation, Turkey, Ataturk University, Medical Faculty, Department of Pathology, Turkey, Ataturk University, Medical Faculty, Department of Pharmacology, Turkey
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پست الکترونیکی
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halis.suleyman@gmail.com,suleyman@atauni.edu.tr
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Authors
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