Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population

Background: role of genetic factors in etiology of preeclampsia is not confirmed yet.objective: gene defect frequency varies in different geographic areas as well as ethnic groups. in this study, the role of factor v leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of persian gulf in iran, were considered.materials and methods: between jan. 2008 and dec. 2009, in a nested case control study, pregnant women with preeclampsia (n=198) as cases and healthy (n=201) as controls were enrolled in the study. dna were extracted from 10 cc peripheral blood and analyzed for presence of factor v leiden mutation in these subjects. the maternal and neonatal outcomes of pregnancy according to the distribution of factor v leiden were also compared among cases.results: in total, 17(8.6%) of cases and 2(1%) of controls showed the factor v leiden mutation. the incidence of factor v leiden was typically higher in preeclamptic women than control group (or: 9.34 %95 ci: 2.12-41.01). there was no difference in incidence rate of preterm delivery< 37 weeks (or: 1.23 %95 ci: 0.38-4.02), very early preterm delivery<32 weeks (or: 1.00 %95 ci: 0.12-8.46), intra uterine fetal growth restriction (iugr) (or: 1.32 %95 ci: 0.15-11.30 ),and the rate of cesarean section (or: 0.88 %95 ci: 0.29-2.62 ) among cases based on the prevalence of factor v leiden mutation.conclusion: the pregnant women with factor v leiden mutation are prone for preeclampsia syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women.