The correlation between follicular fluid anti-mullerian hormone levels and fertilization and embryo quality in ART cycles

Background: determination of oocyte and embryo quality are one of the most important goals in ivf. anti-mullerian hormone (amh) is secreted by the ovarian granulosa cells into blood flow and follicular fluid. follicular fluid anti-mullerian hormone level is probably a marker of activity of granulose cells.objective: to evaluate whether high level of follicular fluid anti-mullerian hormone level is related to success of fertilization and better embryo quality.materials and methods: 62 women, whose follicular fluid sample was obtained from a single follicle in each patient, underwent ivf with gnrh-agonist long protocol. based on oocyte fertilization, the patients were divided into fertilized group (n=42) and non-fertilized group (n=20). ff amh levels were measured in both groups and the quality of embryos was determined in fertilized group.results: median of ff amh level in fertilized group was higher than that in non-fertilized group (5.7ng/ml v.s. 2.7ng/ml) and a statistically significant difference was observed between the two groups. there was a significant difference between ff amh level and scores of embryos (p<0.001). the medians levels of ff amh were 6.7ng/ml in good quality embryos and 3.80ng/ml in fair quality embryos.conclusion: our results indicate that ff amh level has positive correlation with fertilization and embryo quality; therefore, it can be considered as a marker of ivf outcome.