the correlation between insulin-like growth factor binding protein 1 (igfbp-1) and homeostasis model assessment of insulin resistance (homa-ir) in polycystic ovarian syndrome with insulin resistance

Background: the underlying etiology of polycystic ovarian syndrome (pcos) is unknown and assumed to have a strong correlation with insulin resistance. homeostasis model assessment of insulin resistance (homa-ir) is a good tool to assess insulin resistance. low levels of serum insulin-like growth factor-binding protein-1 (igfbp-1) in pcos women led to the hypothesis that hyperinsulinemia in pcos inhibits the production of igfbp-1, which in turn stimulates excessive androgen production. objective: the study is aimed to analyze the correlation between the levels of igfbp-1 and homa-ir on insulin resistance in pcos. materials and methods: a cross-sectional study among 105 pcos women, including 60 women with insulin resistance were recruited. the mean of igfbp-1 and homa-ir were 6.507±4.7821 μg/l and 3.633±1.666 respectively. results: low levels of igfbp-1 were detected in all insulin resistance women. there was a correlation between homa-ir and overweight (p=0.045), while igfbp-1 showed no correlation with overweight (p=0.106). in addition, no correlation between igfbp-1 with homa-ir as a marker of insulin resistance was detected. conclusion: despite the decrease in igfbp-1, it seems that there is no correlation between igfbp-1 with homa-ir as a marker of insulin resistance