influence of body mass index and polycystic ovarian syndrome on icsi/ivf treatment outcomes: a study conducted in pakistani women

Background: obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (pcos) females. objective: to compare results of intra-cytoplasmic sperm injection (icsi) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in pcos females. materials and methods: a cross-sectional study from june 2015 to july 2016 included non-pcos and pcos (recognized by rotterdam criteria) females who underwent icsi. the pcos were further stratified into non-obese and obese according to the south asian criteria for body mass index. results were categorized on the basis of beta-human chorionic gonadotropin (β-hcg) and transvaginal scan into non-pregnant (β-hcg <25 miu/ml), preclinical abortion (β-hcg >25 miu/ml with no fetal cardiac activity) and clinical pregnancy (β-hcg >25 miu/ml with fetal cardiac activity on transvaginal scan). in addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese pcos and non-pcos patients were compared. results: our results revealed 38.5% clinical pregnancy rate in non-pcos females, 23.8% in non-obese pcos females whereas 26.4% in obese pcos. preclinical abortions were found to be highest (31.5%) in non-obese pcos females and were the lowest (26.2%) in non-pcos females. in non-pcos group and non-obese pcos females 35.4% and 44.6%, respectively, failed to become pregnant. conclusion: the success after icsi in terms of number of clinical pregnancies was more in non-pcos patients as compared to pcos. increase in body mass index reflected a negative impact on the reproductive outcome in pcos patients.