The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT

Background: several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia. objective: the present study aims to investigate the effect of multimineral-vitamin d supplements (calcium,magnesium,zinc and vitamin d) and vitamins (c+ e) in the prevention of preeclampsia. materials and methods: in this randomized clinical trial,90 pregnant women were divided into three groups: group a received ferrous sulfate (1 tablet/day) + one tablet of claci-care multimineral-vitamin d containing 800mg calcium,200mg magnesium,8mg zinc and 400 iu vitamin d3 per day; group b received ferrous sulfate (1 tablet/day) + 250 mg vitamin c + 55 mg vitamin e; and the controls received only one ferrous sulfate tablet daily. results: the incidence of preeclampsia in group a was significantly lower than the control group (p=0.03),while there was no significant difference between group b and controls (p=0.50),as well as groups a and b (p=0.063). the incidence of neonatal complications in the group a was significantly lower than the control group (p=0.01),while there was no significant difference between group b and control (p=0.48). conclusion: according to the results,calcium,magnesium,and zinc supplements have a significant effect on the prevention of preeclampsia. in addition,prescription of multimineral-vitamin d during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia. © 2017,research and clinical center for infertitlity. all rights reserved.