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miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
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نویسنده
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Tamaddon Gholamhossein ,Geramizadeh Bita ,Karimi Mohammad Hossein ,Mowla Javad ,Abroun Said
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منبع
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iranian journal of medical sciences - 2016 - دوره : 41 - شماره : 4 - صفحه:334 -339
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چکیده
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Diffuse large b-cell lymphoma is the most common type of non-hodgkin lymphoma. micrornas (mirnas) are endogenous small rna, which can regulate gene expression at the post-transcriptional level. mirna profiling has shown a great potential as novel diagnostic and prognostic biomarkers. the present study was performed at the nemazee teaching hospital (shiraz, iran) from 2011 to 2013.the aim of this study was to assess the deregulation of mirnas profiles in dlbl against hyperplasic reactive lymph node as a normal. this could serve as a biomarker for dlbl. the mircury lnatm microarray was used on the total rna, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo diffuse large b-cell lymphoma patients and 14 normal lymph nodes. the greatest changes were detected in mir-4284 and mir-4484 level in patient’s lymphoma samples. these mirnas can act as a diagnostic biomarker for dlbl.
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کلیدواژه
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Lymphoma . Large B-Cell . Diffuse . MicroRNAs. Microarray Analysis
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آدرس
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tarbiat modares university, School of Medical Sciences, Department of Hematology, ایران, shiraz university of medical sciences, School of Medicine, Department of Pathology, ایران, shiraz university of medical sciences, Nemazee Teaching Hospital, Transplant Research Center, ایران, tarbiat modares university, Faculty of Basic Sciences, Department of Genetics, ایران, tarbiat modares university, School of Medical Sciences, Department of Hematology, ایران
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Authors
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