Comparison of the Wave Amplitude of Visually Evoked Potential in Amblyopic Eyes between Patients with Esotropia and Anisometropia and a Normal Group

Background: we compared the wave amplitude of visually evoked potential (vep) between patients with esotropic and anisometropic amblyopic eyes and a normal group.methods: the wave amplitude of vep was documented in 2 groups of persons with amblyopia (15 with esotropia and 28 with anisometropia) and 1 group of individuals with normal visual acuity (n, 15). the amplitude of p100 was recorded monocularly with different spatial frequencies.results: our statistical analysis revealed that the wave amplitude in the 2 groups with amblyopia was significantly decreased compared to that in the normal group (p<0.001). there was a significant difference regarding the amplitude in high spatial frequencies in both high- and low-contrast conditions between the groups with esotropia and anisometropia and the normal group (p<0.001). there were also significant differences in large check-size stimuli and low-contrast condition between the amblyopic groups with esotropia and anisometropia and the normal group (p=0.013 and p=0.044, respectively). in large check-size stimuli and high-contrast condition, a significant difference was indicated only in the comparison between the esotropic amblyopic eyes and the normal eyes (p=0.036).conclusion: the wave amplitude parameter of vep wasinfluenced by both types of amblyopia, but it seems that thisparameter was more sensitive to esotropic amblyopia thananisometropic amblyopia. this outcome may reflect a nonparallelpattern of cortical responses in the comparison of the2 types of amblyopia with each other and with the control group,which may be beneficial for the diagnosis and treatment ofamblyopia.