Captopril Attenuates Diazinon-Induced Oxidative Stress: A Subchronic Study in Rats

Background: diazinon (dzn) is an organophosphate pesticide commonly used for pest control in agriculture. it may engender a variety of negative effects in non-target species, including humans and animals. the objective of the present study was to evaluate the ameliorative properties of captopril (cap), as a thiol containing an angiotensin-converting enzyme inhibitor, against dzn-induced oxidative stress.methods: twenty-eight male wistar rats were divided randomly into 4 groups. all the rats were treated orally via gavage once a day for 7 weeks: control (corn oil), cap (10 mg/kg), dzn (10 mg/kg), and cap+dzn combination (as mentioned above). oxidative stress indices in blood serum, liver and kidney homogenates (malondialdehyde [mda], total thiol groups, and total antioxidant capacity), and erythrocyte hemolysis (superoxide dismutase [sod] and glutathione peroxidase) were evaluated. statistical analysis was performed using graphpad prism software, version 6.0 (graphpad, san diego, ca, usa), by anova, followed by the tukey post hoc analysis.results: the mda content and sod activity increased significantly in the dzn group compared with those in the control group. treatment with cap in the dzn-exposed group significantly decreased (p<0.05) the mda concentration and the sod activity. the total thiol groups were decreased in the dzn group and elevated again by cap treatment. conclusion: the co-administration of cap and dzn was able to attenuate lipid peroxidation and enzyme changes caused by dzn.