The Responsibility of the Institutional Review Board in Good Clinical Practice: First, Do NoHarm

I read with interest the article on outpatient management of burn wounds published in a recent issue of theijms.1 there are many questions that arise which are worth mentioning. under the methodology section,no description was provided on how patients were randomized into the two treatment arms and, therefore,it is not possible to assess how confounding variables were controlled. based on the data presented in table3 of the article, the pain score before dressing was significantly lower in the “amnion group” than the“control group”. this might reflect degrees of bias in assigning patients to the study groups. consequently,as expected, the pain score measured after dressing and the dose of analgesics consumed were lower inthe “amnion group” than in the “control group” (table 3 of the article).