A rare case of fixed drug eruption due to ondansetron

Fixed drug eruption (fde) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. fde is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. a 27-year-old woman presented with multiple dark patches over her eyelids,mouth,lips,and shoulders of 1 week’s duration. these lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet,12 days previously. the case was diagnosed as post-inflammatory hyperpigmentation following ondansetron-induced fde. there was an identical episode 1 year earlier due to the intake of the same drug. the causality assessment pointed toward a probable/likely association as per the naranjo algorithm and the who–umc scale. there have been only a few cases of fde due to ondansetron in the reported literature. © 2017,shiraz university of medical sciences. all rights reserved.