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An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study
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نویسنده
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vafaee reza ,nikzamir abdolrahim ,razzaghi mohhamadreza ,rezaei tavirani sina ,ahmadzadeh alireza ,emamhadi mohammad ali
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منبع
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journal of lasers in medical sciences - 2020 - دوره : 11 - شماره : Supplement - صفحه:101 -106
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چکیده
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Introduction: genomics and bioinformatics are useful methods for exploring unclear aspects of radiation effects on biological systems. many radiation-induced alterations in irradiated samples are post-radiation time-dependent. this study aims to evaluate the post-irradiation effects of the gamma ray on human jurkat cells. methods: gene expression profiles of the samples harvested 6 and 24 hours after radiation to find the critical differential expressed genes and the related pathways. samples are provided from gene expression omnibus (geo) and analyzed by cluego. results: twnety-nine critical genes were determined as the important affected genes and 7 classes of related pathways were introduced. ccne2, psmd11, cdc25c, anapc1, plk1, aurka, and ccnb1 that were associated with more than 6 pathways were related to one of the determined pathway groups. conclusion: cell protecting pathways were associated with the genes (hspa5, hspa8, hsp90b1, hmmr, cebpb, rxra, and psmd11) which were related to the minimum numbers of pathways. the finding of this study corresponds to repair processes which depend on post-radiation time. it seems these sets of genes are suitable candidates for further investigation.
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کلیدواژه
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Radiation ,Bioinformatics ,Gene expression ,Pathway ,Dysregulation
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آدرس
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shahid beheshti university of medical sciences, faculty of paramedical sciences, proteomics research center, Iran, shahid beheshti university of medical sciences, faculty of medicine, Iran, shahid beheshti university of medical sciences, laser application in medical sciences research center, shahid beheshti university of medical sciences, gastroenterology and liver diseases research center, research institute for gastroenterology and liver diseases, Iran, shahid beheshti university of medical sciences, faculty of medicine, Iran, shahid beheshti medical university, forensic medicine department, Iran
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پست الکترونیکی
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emamhadi2000@gmail.com
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Authors
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