Laser Treatment of Darier Disease: Report of Two Cases and Systematic Review of the Literature

Introduction: darier disease (dd) is a chronic disease with high morbidity and limited treatment options. laser efficacy in the treatment of dd remains understudied. methods: a literature search conducted between 07/21/2017 and 05/05/2018 identified all original cases of dd treated with laser therapy. results: outcomes from 24 patients were reviewed, 22 patients were identified in the literature and 2 cases are included from our institution. five types of lasers were identified [co_2 laser, er:yag laser, pulse dye laser [pdl], diode laser, erbium-doped fiber laser], with co_2 (46%) and pdl (42%) being the most common. seventy-nine percent of patients were treated with more than one procedure (average, 3 procedures). the estimated body surface treated with each session ranged from 5%-50%. the most common adverse events came from co_2 and er:yag lasers and included dyspigmentation, pain, and post-laser erythema and edema. the time to response (mode, 1 month) was only reported in half of the studies. conclusion: laser treatments appear to be a promising alternative to standardized therapies in dd.