Successful Use of the 308-nm Excimer Laser in Early Patch Stage Mycosis Fungoides

Introduction: mycosis fungoides (mf), a type of cutaneous t-cell lymphoma, is a rare condition with a variety of treatment options. a frequently utilized method in the treatment of early-stage mf is phototherapy. full body phototherapy can be associated with photoaging of the skin and an increased risk of developing skin cancer. targeted phototherapy, with a 308-nm excimer laser, may be just as effective and of a lower risk. this makes it especially useful in the treatment of patients with dysplastic nevi (dn) or other conditions which can put them at a higher risk of developing skin cancer. there are currently limited data on the treatment of early-stage mf with an excimer laser. case report: this study reports on a 43-year-old female patient presented to the clinic with early- stage (ia) mf. given her history of dn, she wished to pursue targeted phototherapy with an excimer laser. localized light treatment was performed via a 308-nm excimer laser, 3 times weekly, for a total of 17 treatments to affected lesions. following excimer laser treatment, she had a clinical resolution of her patches. on the follow-up clinic visits, she maintained her excellent response 12 months out. conclusion: targeted phototherapy with a 308-nm excimer laser may be a safer and equally effective alternative to generalized phototherapy in the treatment of early-stage mf. this case report demonstrates its efficacy and advantages over traditional generalized phototherapy.