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   The Combined Effects of Mesenchymal Stem Cell Conditioned Media and Low-Level Laser on Stereological and Biomechanical Parameter in Hypothyroidism Rat Model  
   
نویسنده sefati niloofar ,abbaszadeh hojjat-allah ,fadaei fathabady fatemeh ,abdollahifar mohammad-amin ,khoramgah maryam-sadat ,darabi shahram ,amini abdollah ,tahmasebinia foozhan ,norouzian mohsen
منبع journal of lasers in medical sciences - 2018 - دوره : 9 - شماره : 4 - صفحه:243 -248
چکیده    Introduction: many studies have shown the positive effect of laser radiation and application of the mesenchymal stem cells (mscs) and their secretion in stimulating bone regeneration. the aim of this study was determining effects of msc conditioned media (cm) and low-level laser (lll) on healing bone defects in the hypothyroid male rat. methods: we assigned 30 male wistar rats randomly to 3 groups: control, hypothyroidism, cm +lll. four weeks after surgery, the right tibia was removed. biomechanical examination and histological examinations were performed immediately. results: our results showed significant increase in bending stiffness (116.09 ± 18.49), maximum force (65.41 ± 8.16), stress high load (23.30 ± 7.14), energy absorption (34.57 ± 4.10), trabecular bone volume (1.34 ± 0.38) and the number of osteocyte, osteoblast, and osteoclast (12.77 ± 0.54, 6.19 ± 0.80, 1.12 ± 0.16 respectively) in osteotomy site in the lll + cm group compared to the hypothyroidism group (p < 0.05). conclusion: the results indicated that using the lll + cm may improve fracture regeneration and it may hasten bone healing in the hypothyroid rat.
کلیدواژه Hypothyroidism; Low-level laser; Conditioned Media
آدرس shahid beheshti university of medical sciences, school of medicine, department of biology and anatomical sciences, Iran, shahid beheshti university of medical sciences, hearing disorders research center, loghman hakim medical center, school of medicine, department of biology and anatomical sciences, Iran, shahid beheshti university of medical sciences, laser application in medical sciences research center, school of medicine, department of biology and anatomical sciences, Iran, shahid beheshti university of medical sciences, school of medicine, department of biology and anatomical sciences, Iran, shahid beheshti university of medical sciences, hearing disorders research center, loghman hakim medical center, Iran, qazvin university of medical science, cellular and molecular research center, Iran, shahid beheshti university of medical sciences, school of medicine, department of biology and anatomical sciences, Iran, institute for advanced studies in basic sciences (iasbs), department of biological sciences, Iran, shahid beheshti university of medical sciences, laser application in medical sciences research center, school of medicine, department of biology and anatomical sciences, Iran
پست الکترونیکی norozian93@gmail.com
 
     
   
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