The effect of probe pressure on in vivo single fiber reflectance spectroscopy

Introduction: single fiber reflectance spectroscopy (sfrs) is a noninvasive procedure to quantitate tissue absorption and scattering properties. it can be used to diagnose different diseases such as malignancy and pre-cancerous conditions. the measurement is done with a fiber optic probe in contact with the tissue surface. herein,the effect of probe pressure on the extracted parameters from human lip spectra was studied. methods: thirty-three normal subjects were examined with three exerted pressure levels on the right,middle and left parts of their lips. results: the results showed variation of spectroscopic parameters with different pressure levels. however,the effect was seen between a very mild contact (pressure 1) and the other reasonably practical pressure levels normally used in the medical centers. conclusion: sfrs can be used as a reliable diagnostic tool in clinics.