Determination of the Lipid Profile of Cord Blood in Neonates and its Correlation with Maternal Age in Iran

Background: cardiovascular diseases (cvds) are the leading cause of mortality in iran; with dyslipidemia as an important contributing risk factor.objectives: to assess the early onset of dyslipidemia, our goal was to determine lipids and lipoproteins levels in cord blood and their correlation with maternal age as a first study in iran.patients and methods: this cross sectional study was done on the cord blood of 243 healthy, full-term newborn infants (114 females and 129 males). the blood was sampled from the umbilical cord immediately after a normal delivery. the serum was tested in order to determine the lipid profile including total cholesterol (tc), triglycerides (tg) and high density lipoprotein-cholesterol (hdl-c). low density-lipoprotein (ldl-c) was computed by friedewald equation.results: a statistically significant negative correlation was observed between cord blood hdl-c and maternal age (r = -0.18, p <0.01). there was no relationship between other lipids and lipoproteins with maternal age. our findings also showed the tc, tg and ldl-c mean level were significantly more and the mean level of hdl-c was significantly lower than reference value. additionally, the mean of tc and ldl-c in female neonates were significantly more than the male (p <0.01). also, there was no correlation between cord blood lipids and lipoproteins with birth weight and maternal body mass index (bmi).conclusions: in a current study based on increasing maternal age, the hdl-c level in cord blood was decreased which is an independent risk factor for cvds in adulthood.