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   efficacy of inhaled colistin in critically ill children with ventilator-associated pneumonia resistant to multiple drugs  
   
نویسنده khanbabaee ghamartaj ,mir jafari maryam ,behzad azita ,hashemi masumeh ,ahmadizadeh narjes ,alemzadeh maryam ,mirrahimi bahador
منبع journal of comprehensive pediatrics - 2024 - دوره : 15 - شماره : 4 - صفحه:1 -7
چکیده    Background: ventilator-associated pneumonia (vap) is the leading cause of death related to mechanical ventilation and the most common nosocomial infection in the intensive care unit (icu).objectives: this study aimed to investigate the efficacy of adjunctive inhaled colistin in critically ill children with multidrug-resistant ventilator-associated pneumonia (mdr-vap). methods: in this prospective cohort study, 80 critically ill patients aged 2 to 18 years with mdr-vap were admitted to the picu of mofid children's hospital in tehran between 2019 and the end of 2022. eligible patients were divided into two equal groups: the colistin group (receiving inhaled colistin in addition to other antibiotics) and the control group (receiving only intravenous antibiotics). clinical and laboratory findings were compared between the two groups. results: the mean ages of participants in the control and colistin groups were 21.2 ± 2.9 and 24.9 ± 1.7 months, respectively (p = 0.51). the duration of hospital stay in the colistin group was 34.92 ± 20.03 days, compared to 29.83 ± 22.35 days in the control group, which was not statistically significant (p = 0.29). the duration of mechanical ventilation use was similar between the control group (23.15 ± 21.17 days) and the colistin group (24.06 ± 17.87 days) (p = 0.83). mortality rates were also comparable, with 65% in the control group and 57.5% in the colistin group (p = 0.49). conclusions: inhaled colistin did not significantly reduce the duration of hospitalization, the duration of mechanical ventilation use, or the mortality rate in critically ill children with mdr-vap. further multicenter studies with larger sample sizes are recommended to validate these findings.
کلیدواژه colistin ,gram negative bacteria ,ventilator-associated pneumonia ,pediatrics
آدرس shahid beheshti university of medical sciences, mofid children’s hospital, department of pediatric pulmonology, iran, shahid beheshti university of medical sciences, mofid children's hospital, iran, shahid beheshti university of medical sciences, mofid children's hospital, iran, shahid beheshti university of medical sciences, mofid children's hospital, iran, shahid beheshti university of medical sciences, mofid children's hospital, iran, shahid beheshti university of medical sciences, mofid children's hospital, iran, shahid beheshti university of medical sciences, faculty of pharmacy, department of clinical pharmacy, iran
پست الکترونیکی mirrahimi@yahoo.com
 
     
   
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