the prevalence of low birth weight in children with nephrotic syndrome

Background: nephrotic syndrome (ns) is a common disease in children with many consequences for their health, particularly when the disease is severe, accompanied by frequent recurrences, and must be treated with high-dose, long-term corticosteroids. objectives: we aimed to determine the effect of birth weight on complete response to corticosteroids in children with ns. methods: two hundred and ninety-two children with ns aged 1 - 18 years were included in the present cross-sectional study. the children followed up from 2010 to 2021 at ali-ibn-e-abitaleb hospital, zahedan, iran. data were obtained by reviewing medical records for results and completing a parental self-reported questionnaire for birth-related information. for the analysis, spss 23 was applied with p < 0.05 as a significance level. results: in the steroid-resistant (28.9%) group, low birth weight (lbw) was significantly higher than in the steroid-sensitive (10.5%) group (p = 0.001). a two-way logistic regression report showed that birth weight (p = 0.04, or = 0.58, 95% ci: 0.34 - 0.99) and number of recurrences (p = 0.001, or = 4.60, 95% ci: 2.91 - 7.27) were both significantly associated with the development of steroid resistance. conclusions: in patients with ns, there was a significant association between lbw, higher relapse rates, steroid resistance, and thus poorer patient outcomes.