Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children

Background: the present study evaluated efficacy of a single injection of ceftriaxone 50mg/kg im in comparison with a 10- day treatment course with oral amoxicillin 50mg/kg/d in 3 divided doses for acute otitis media in children. materials and methods: a randomized clinical trial was performed on 110 children between 5 months to 12yr who randomly were divided in to ceftriaxone group (n=54) and amoxicillin group (n=56) as case and control groups, respectively. results: demographic data and clinical manifestations of patients were similar in both groups.forty-eight (88.9%) and 51 (91%) patients were cured in case and control groups, respectively. there was no significant different in response to therapy between the two group (p<0.05).conclusion: this study showed that the efficacy of single injection of ceftriaxone 50mg/kg im was equal to a 10-day treatment course with oral amoxicillin 50mg/kg/d divided in 3 doses in non-complicated acute otitis media in children.