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Biotransformation of Monoterpenoids by Suspension Cultures of Lavandula angustifolia
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نویسنده
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Shams Ardekani Mohammad Reza ,Linley Peter A ,Harkiss Keith J ,Mohagheghzadeh Abdolali ,Gholami Azra ,Mosaddegh Mahmood
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منبع
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iranian journal of pharmaceutical sciences - 2007 - دوره : 3 - شماره : 2 - صفحه:93 -100
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چکیده
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Callus and suspension cultures of lavandula angustifolia mill. (lamiaceae) were established and the effect of different culture media on growth rate was investigated. terpenoids added to suspension culture to investigate their biotransformation. all samples were analyzed by gas chromatography (gc) and gc-mass spectroscopy (ms). octan-1-ol, citronellol, linalool, borneol and geraniol were biotransformed products of octanal, citronellal, linalyl acetate, bornyl acetate and geranyl acetate, respectively. citronellol, linalool, borneol, and menthol didn't change by l. angustifolia suspension cultures. blue pigment production by cultures of l. angustifolia was also studied. ester hydrolysis and oxidation were the main reactions which occurred in biotransformation process, which may be attributed to the presence of related or bifunctional enzymes. this technique is a possible way of the production of expensive or rare compounds from cheap and plentiful substrates.
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کلیدواژه
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Biotransformation; In vitro cultures; Lavandula angustifolia; Terpenoids.
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آدرس
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tehran university of medical sciences tums, Faculty of Pharmacy, Department of Pharmacognosy, ایران, University of Bradford, School of Pharmacy, UK, University of Bradford, School of Pharmacy, UK, shiraz university of medical sciences, Faculty of Pharmacy, Pharmaceutical Research Center, Department of Pharmacognosy, ایران, shiraz university of medical sciences, Faculty of Pharmacy, Pharmaceutical Research Center, Department of Pharmacognosy, ایران, shahid beheshti university of medical sciences, Traditional Medicine and Materia Medica Research Center, ایران
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پست الکترونیکی
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ardekani@sina.tums.ac.ir
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Authors
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