Protective Effects of Lycopene and Tomato Extract Against Doxorubicin-Induced Cardiotoxicity

The protective effect of tomato extract and lycopene on acute doxorubicin-inducedmyocardial toxicity was evaluated in mice. doxorubicin toxicity, induced by asingle intraperitoneal injection (15 mg/kg), was revealed by elevated serum cpkmband histopathological observations. tomato extract (1.2 and 2.4 g/kg, i.p.) andlycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum cpkmb andameliorated cardiac cell injury. these results suggest that tomato extract andlycopene inhibit doxorubicin-induced cardiotoxicity and might serve as a combinationchemotherapeutic agent with doxorubicin to limit its cardiotoxic effects.