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Effects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum
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نویسنده
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Hadizadeh Farzin ,Anaraki-Firooz Bibi Fatemeh ,Husain Taqvi Syed Intasar
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منبع
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iranian journal of pharmaceutical sciences - 2005 - دوره : 1 - شماره : 1 - صفحه:25 -28
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چکیده
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In order to investigate the effects of dimethylamino substituent at postion 2of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethylamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicarboxylates (6a-f) were synthesized. the synthesis was started fromdialkyl 1,4-dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channelantagonist on guinea-pig ileum has been reported previously. rabbit jejunum wasused to determine the relaxant or antagonistic activity of the synthesized compounds.some of the compounds (6c-e) inhibited the spontaneous contractile activity ofjejunum, dose-dependently and completely, while high-k+ contracted tissues wererelaxed partially.
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کلیدواژه
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2-Dimethylamino-substituted dihydropyridines; Rabbit jejunum; Calciumchannel
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آدرس
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mashhad university of medical sciences, Department of Medicinal Chemistry, ایران, Biotechnology and Pharmaceutical Sciences Research Center, ایران, Jinnah Medical and Dental College, Department of Pharmacology, Pakistan
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پست الکترونیکی
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f-hadyzadeh@mums.ac.ir
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Authors
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