Preparation and Characterization of PLGA Microspheres Loaded by Cyclosporine-Cyclodextrin Complex

The purpose of this study was to prepare and characterize microspheres loadedby cyclosporine a(cya)-cyclodextrin (cd) complex. to achieve this goal, plgamicrospheres loaded by cya-cd complex were prepared by multiple emulsificationsolventevaporation methods. morphology, size, encapsulation efficiency and drugrelease from these microspheres were evaluated. microscopic evaluation ofmicrospheres showed that microspheres were spherical in shape. the size analysisresults indicated that size range varied from 1 to 50 mm for complex loadedmicrospheres. encapsulation efficiency of microspheres was increased by increasingdrug to polymer ratio. drug release was found to be biphasic with a first more rapidrelease phase (burst) followed by a slower phase. after two weeks, 43.40%±3.45of cya was released from these microspheres. in conclusion, microspheres loadedwith cya-cd complex were prepared that could be used for control delivery of cya.