In-Vitro Study of Dipyridamole–Propranolol Interaction in Protein Binding in the Absence and Presence of Nicotine

The binding of drugs by plasma proteins is an important phenomenon, becauseit influences the size of the free fraction of the drugs in plasma. in this study theinfluence of dipyridamole (dp) on the protein binding of propranolol (pl) and plon the protein binding of dp were studied alone and in the presence of nicotine (nc).the equilibrium dialysis was employed for protein binding studies. results showedthat dp (10 ىg/ml) increased the protein binding of pl (1-40 ىg/ml) by 4.1%, andpl(30 ىg/ml) decreased the protein binding of dp (1-30 ىg/ml) by 3.7%. nc (2 ىg/ml)did not have any influence on the protein binding of pl and dp. therefore, coadministrationof pl and dp may cause an alteration in their pharmacological effects,but cigarette smoking possibly does not change protein binding of pl and dp.