Effect of Nepeta glomerulosa Boiss. Aerial Parts Aqueous Extract on Morphine Withdrawal Syndrome in Mice

The effect of aqueous extract of nepata glomerulosa boiss. aerial parts onmorphine withdrawal syndrome was investigated in mice. dependence was inducedby subcutaneous injections of morphine for 3 consecutive days. on day 4, morphinewas injected 2 h prior to intraperitoneal injection of naloxone. the number ofjumps during a 20 min. period after naloxone injection was considered as a measureof the withdrawal syndrome. open field and rotarod tests were also performed. theresults indicated that the aqueous extract (0.1 to 2.8 g/kg, s.c.) and diazepam (5 mg/kg)reduced the number of jumps (58±2.3 to 10±0.82, p<0.001 vs normal saline,87±3.4). the extracts also reduced motion balance and locomotion activity. it isconcluded that the aqueous extract of n. glomerulosa aerial parts could diminishmorphine withdrawal syndrome.