Synthesis and Evaluation of Antimicrobial Activity of Metal Complexes of 4-(2'-Hydroxy Phenyl Imino) Phenyl Sulphonamide

Keeping in view the promising potential of carbonic anhydrase inhibitor basedantimicrobials and enhancement of carbonic anhydrase inhibitory activity bymetal complexes of sulfonamides, with an aim to develop better antimicrobial agentswe have attempted investigation of antimicrobial activity of metal complexes of4-(2'-hydroxy phenyl imino) phenyl sulphonamide. sulfanilamide was taken as thestarting material to synthesize 4-(2'-hydroxy phenyl imino) phenyl sulphonamide.cu (ii), zn (ii), co (ii), ni (ii) and pb (ii) complexes were synthesized followingreported methods. the in vitro screening was carried out using two gram positivebacteria (s. aureus, e. faecalis) and two gram-negative bacteria (e. coli, p.aeruginosa) by disc diffusion method. metal complexes were found to enhance theantimicrobial potental of the ligand.