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Synthesis and Study of Antitumor Activity of Substituted Imidazolecarboxamides
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نویسنده
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Hadizadeh Farzin ,Ramezani Mohammad ,Tayarani Zahra ,Eghbal Maryam
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منبع
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iranian journal of pharmaceutical sciences - 2007 - دوره : 3 - شماره : 4 - صفحه:239 -244
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چکیده
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In view of potential biological activities of small molecule poly amides, wesynthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-lh-imidazole-5carboxamide(7a,b), and n-(2-(l-benzyl-2-(alkylthio) -hl-imidazole- 5-carboxamido)ethyl)-1-benzyl-2- (alkylthio)-lh-imidazole-5-carboxamides (8a,b) as antitumoragents. the antitumor activity of compounds 7a,b and 8a,b was studied atconcentrations of 0.01,0.1 and 1 mg/ml, using the potato disk bioassay technique.vincristine at 0.25 mg/ml employed as positive control and had -67.24% tumorinhibition. maximum % inhibition for potato tumors was found to be -75.52 for 7bat 1 mg/ml.
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کلیدواژه
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Antitumor; Imidazoecarboxamide; Potato disc.
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آدرس
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mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center, ایران, mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center, ایران, mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center, ایران, mashhad university of medical sciences, Faculty of Pharmacy, ایران
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پست الکترونیکی
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hadizadehf@mums.ac.ir
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Authors
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