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Exploring the Protective Effect of Ascorbic Acid and Aqueous Extract of Spirulina platensis on Methotrexate-Induced Lipid Peroxidation
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نویسنده
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Ray Supratirn ,Roy Kunal ,Sengupta Chandana
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منبع
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iranian journal of pharmaceutical sciences - 2007 - دوره : 3 - شماره : 4 - صفحه:217 -228
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چکیده
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This study was designed to explore the protective effects of ascorbic acid andwater extract of spirulina platensis (blue green algae) on methotrexate-induced lipidperoxidation using goat liver as the lipid source. thi s in vitro evaluation was doneby measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione andnitric oxide content of tissue homogenates. the study reveals the lipid peroxidationinduction capacity of methotrexate, the anti -peroxidative potential of ascorbi c acidand aqueous extract of s. jjlatensis on methotrexate-induced lipid peroxidation.
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کلیدواژه
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Ascorbic acid; Lipid peroxidation; Methotrexate; Nitric oxide; Reducedglutathione; Spirulina platensis.
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آدرس
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Himalayan Pharma cy Institut e, Division of Pharmac eutical Chemistry, India, Jadavpur University, Division of Pharmac eutical Chemistry, Department of Pharmaceutical Technology, India, Jadavpur University, Division of Pharmac eutical Chemistry, Department of Pharmaceutical Technology, India
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پست الکترونیکی
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supratimray_in@yahoo.co.in
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Authors
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