Studies on the Charge-Transfer Interaction Between Tamoxifen Citrate and Chloranilic Acid

Abstractthe complex formed as a consequence of the interaction between the electronacceptorp-chloranilic acid and an electron donor tamoxifen citrate was employedin the assay of the drug in pure powder and tablets. chloranilic acid was found toform a charge-transfer complex in a 1:1 stoichiometric ratio, with tamoxifen citrate.the wavelength of maximum absorption for the complex was found to be 550 nmwhile the absorbance was linear over the concentration range of 2-100 g/ml.evaluations of the various thermodynamic parameters by means of the scottequation was carried out and were found to decrease with increase in temperature.the free energy change (l1go) and the enthalpy of formation (l1ho) as well as theentropy (l1s 0) were determined for various interactions. results obtained suggestthat the proposed method may be conveniently applied in the analysi s ofcommercially available.tamoxifen citrate tablets with a high degree of accuracy andreproducibility.