Preparation and Evaluation of Polymeric Nanofibers Containing Griseofulvin –Microemulsion by Electrospinning Process

In this study, the purpose of preparing cs/pva nanofibers loaded grf microemulsion is to increase the solubility of low soluble drug griseofulvin by using microemulsion nanocarrier, and nanofiber was used as a technique for a new product. this drug is one of the antifungal drugs, and its uses are for skin diseases. therefore, a topical route can be a good option. chitosan /polyvinyl alcohol (cs/pva) nanofiber containing griseofulvin (grf) loaded microemulsion was obtained. the microemulsion comprised oleic acid and transcutol p as the oil phase, span20 and labrasol as the surfactant, and plurol oleique as the cosurfactant. formulations were prepared with a me(grf): polymer ratio (30: 70) and (40: 60) and a polymeric solution containing chitosan (2%) and polyvinyl alcohol (10%) at two weight ratio (20: 80) and (10: 90), respectively. the physicochemical characteristics of the grf-cs/pva nanofibers were evaluated. the differential scanning calorimetry (dsc) study showed the amorphous state of the grf-loaded microemulsions and pva polymer embedded into the nanofibers. the entrapment efficiency percentage of grf in the mats was approximately 66.67% - 88.89%. drug release behavior showed controlled and slow release of drugs that are affected by the type of microemulsion formulation and the ratio of polymers used in nanofibers.