Design, Synthesis and Docking studies of New Quinazolinone Derivatives as Anti-HIV-1 Agents

The human immunodeficiency virus (hiv) infection is a global health challenge that creates an urgent need to develop new therapeutic agents. in this work, a new group of quinazolinone derivatives were designed and synthesized and evaluated their anti-hiv activity. the antiviral assay revealed that some analogues inhibited hiv replication in the cell culture. a docking study using the later crystallographic data available for pfv integrase including its complexes with mg2+ and dolutegravir, showed that the designed compounds bind into the active site of integrase enzyme such that both carbonyl groups chelate mg2+ ions. interestingly, all of the synthesized compounds were found to present no significant cytotoxicity at a concentration of 100 μm. according to the anti-hiv evaluation results, the compound 10f was found as the most active with the inhibition rate of 38%. therefore, these compounds can provide a very good basis for the development of new anti-hiv agents.