Therapeutic Potential of Astaxanthin Against Cadmium-Induced Hepatic Failure: An Experimental Study

Cadmium is a toxic metal that can lead to liver failure in humans and animals. astaxanthin (asx) is one of the well-known xanthophyll carotenoids in food that has remarkable antioxidant properties. hence, this study investigated the effect of asx against cadmium-induced hepatic failure. twenty-four mice were divided into four groups of six each and treated intraperitoneally as follows: group 1 (sham) received normal saline and olive oil; group 2 received 10 mg/kg/day of asx; groups 3 and 4 were treated with cadmium (1 mg/kg/day) and asx (10 mg/kg/day) + cadmium (1 mg/kg/day), respectively. after 14 consecutive days, mice were sacrificed and blood and liver samples were isolated for histopathological and biochemical experiments. our findings showed a significant increase in serum alanine aminotransferase level, as a hepatic marker, following cadmium administration (p < 0.05). in this regard, cadmium led to hepatic leukocyte infiltration, dilated sinusoids, and increased hepatic metallothionein level (p < 0.01). following the administration of asx, a significant improvement was found in the metallothionein level and hepatic enzymes alongside histopathologic alterations. the present study revealed that the administration of asx could prevent cadmium-induced hepatic failure, which may be related to the antioxidant properties of this carotenoid.