Synthesis and Anti-Tubercular Activity of 6-Substtitutedaryl-4-Arylidene- 4, 5-Dihydropyridazin-3(2H)-One Derivatives against Mycobacterium Tuberculosis

Several 4-substituted-benzylidene-6-substituted-phenyl-4,5-dihydro-pyridazin-3(2h)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. in the first step, 6-aryl-2, 3, 4, 5-tetrahydro-pyridazin-3-ones (2) was prepared by reacting 4-aryl-4- oxobutanoic acids (1) with hydrazine hydrate. then, aryl-aldehydes were reacted with compounds 2 to furnish pyridazinones (3a-q). finally, the synthesized compounds were evaluated for their in vitro antitubercular activities against mycobacterium strains and compared to reference drugs streptomycin (mic value of 6.25μg/ml) and pyrizinamide (mic value of 3.125μg/ml). compound 3m and 3n was found to have most significant action. identity of these compounds was ascertained using ir, nmr and mass spectral data results.