Comparison of Antibiotic Sensitivity of Prevalent Bacteria Isolated from Urinary Tract Infections in 2002 and 2006 in Urmia, Iran

Urine specimens collected from in-patients and out-patients in urmia imam hospital, northwest iran, were cultured on blood agar and eosin methylene blueagar. isolated bacteria were identified according to standard microbiological testsand then subjected to sensitivity testing according to routine method of disk agardiffusion technique. out of 8044 and 10425 urine specimens, 8.7% and 11.9% wereidentified as having urinary tract infection (uti) in 2002 and 2006, respectively. themost prevalent bacteria belonged to enterobacteriaceae family and in the case of totalsusceptibility the upmost resistance was recorded against trimethoprim-sulfamethoxazole(62%) and gentamicin (50%) in 2002, and increased to 69% and 57% in 2006,respectively. the least resistance recorded was to ceftizoxim as 15.6% and 16.8 %in 2002 and 2006, respectively. antibiotics susceptibility of in-patients wassignificantly lower than that of out-patients and this was more obvious for cephalosporins. our findings show a remarkably high prevalence of resistance tothe majority of commonly used antibiotics in utis, with a decreasing trend in their activities which probably is due to the high rate of antibiotics use in iran as the firstreason. results of the present study underline the need for sensitivity tests prior toantibiotic therapy in uti, which could help and guide in proper choosing of antibiotics and effective treatment and, therefore, prevention of antibiotic resistance.