Design, Evaluation and Comparative Study of Pulsatile Release from Tablet and Capsule Dosage Forms

The objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lotof interest as they deliver the drug at the right site of action at the right time and inthe right amount, thus providing spatial and temporal delivery and increasingpatient compliance. these systems are designed according to the circadian rhythm of the body. the principle rationale for the use of pulsatile release is for the drugswhere a constant drug release, i.e., a zero-order release is not desired. the releaseof the drug as a pulse after a lag time has to be designed in such a way that a completeand rapid drug release follows the lag time. conclusively, the current study attainedthe successful comparison of drug release from two different pulsatile drug deliverysystems.