Cytotoxicity of Euphorbia macroclada on MDA-MB-468 Breast Cancer Cell Line

It has been reported that different species of euphorbia (euphorbiaceae) haveantitumor activity. some reports also show that these plants have potential cytotoxiceffect against different cell lines. in a program to screen the cytotoxicity of iraniannative plants, euphorbia macroclada boiss. was collected, identified, and thecytotoxic activity of dichloromethane, ethylacetate, methanol extracts, and theplant latex were determined against mda-mb-468 cell line. different concentrationof extracts and latex were added to 24 h cultured cells and then incubated for 72 hunder specific condition (37 °c, 5% co2). cell survival was evaluated using mttassay. the results of this study indicated that, dichloromethane and ethylacetateextracts had cytotoxic effects on cell line, while the methanol extract and latex werenot cytotoxic at the tested concentrations. the data from this investigation suggestthat the nonpolar extracts of e. macroclada possess higher cytotoxic activity.