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Comparison of the Effect of Hydrophilicity on Biocompatibility and Platelet Adhesion of Two Different Kinds of Biomaterials
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نویسنده
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Bonakdar Shahin ,Orang Fariba ,Rafienia Mohammad ,Imani Rana
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منبع
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iranian journal of pharmaceutical sciences - 2008 - دوره : 4 - شماره : 1 - صفحه:37 -44
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چکیده
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Determination of blood compatibility is an important problem in blood contactingdevices. in this study, two classes of materials including polyurethane (based onpolyethylene glycol and poly tetrametylene oxide) and polyvinyl alcohol samples,with different hydrophilicity properties were synthesized and their physico-chemicalproperties were compared. water uptake ratio , ffir spectroscopy, and contactangle measurement were conducted. in vitro biocompatibility experiments wereundertaken using l-929 fibroblast cell lines which demonstrated desired cellviability for all samples after 7 days. the adhesion of platelets from human plasmawas studied by optical microscopy. blood coagulation time were also determinedwhich revealed polyurethane based poly tetramethylene oxide has better interactionby blood elements among all samples.
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کلیدواژه
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Biomaterial; Hydrophilicity; Platelet adhesion; Polyurethane; Polyvinylalcohol.
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آدرس
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islamic azad university, Biomedical Engineering Department, ایران, amirkabir university of technology, Biomedical Engineering Department, Biomaterials Group, ایران, isfahan university of medical sciences, School of Medicine, Piysics and Biomedical Engineering Department, ایران, amirkabir university of technology, Biomedical Engineering Department, ایران
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پست الکترونیکی
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shahinbonakdar@yahoo.com
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Authors
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