evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: a randomized clinical trial

Background. various treatment modalities, such as leucocyte platelet-rich fibrin (l-prf), bone grafts, and membranes, have been used for the restoration of lost periodontal tissues. titanium-prepared platelet-rich fibrin (t-prf) has attracted attention for its proper haemocompatibility, thick fibrin meshwork, and long resorption time. the present study aimed to evaluate the effectiveness of t-prf and l-prf in the management of intra-bony defects based on clinical and radiographic criteria. methods. twenty-six subjects with 34 intra-bony 3- walled defects were divided into two groups (n=17) and treated with t-prf or l-prf. clinical and radiographic measurements were recorded at baseline and 6- , 3- and 9- month intervals and tabulated on microsoft excel spreadsheets. for intra- and inter-group comparisons, paired and unpaired t-tests were performed. p<0.05 was set as statistically significant results. intra-group comparisons revealed statistically significant differences (p<0.05) from baseline in both groups regarding clinical measurements. on intergroup comparison, the t-prf group exhibited a significantly higher defect fill compared to the l-prf group (p<0.05). conclusion. within the limits of the present study, t-prf seems to be a better alternative to l-prf in the treatment of intra-bony defects.