effects of adjective use of melatonin and vitamin c in the treatment of chronic periodontitis: a randomized clinical trial

Background. melatonin can eliminate free radicals and this function can be intensified by vitamin c. melatonin and vitamin c can have synergic antioxidant effects. the aim of thisstudy was to investigate the effects of adjunctive use of melatonin and vitamin c in the non-surgical treatment of chronic periodontitis. methods. sixty subjects with chronic periodontitis were included in this study and randomly allocated to three groups: group 1) 20 patients received non-surgical periodontal treatment; group 2) 20 patients received non-surgical periodontal treatment with adjunctive use of melatonin; and group3) 20 patients received non-surgical periodontal treatment with combination use of melatonin + vitamin c. clinical parameters (pd, cal,gi) were recorded at baseline and at 3-month and 6-month intervalsafter treatment. data were analyzed with paired t-test, one-way anova andrepeated-measures anova. a significant difference was assumed at p<0.05. results. non-surgical periodontal therapy improved pd and cal 3 and 6 months treatment compared to baseline (p<0.001). there was a significant improvement in pd and cal scores at 6-month interval compared to 3 months in the melatonin+ vitamin c group (p<0.05), while the differences in pd and cal scores between the mentioned intervals were not significant between the control and melatonin groups (p>0.05). therefore adjunctive dose of vitamin c offered an additional effect at this interval. conclusion. combination therapy with melatonin and vitamin c can improve the results of non-surgical periodontal therapy.