Determination of Antibodies (IgG, IgM) against Toxoplasma gondii in Patients with Cancer

Background: the aim of this study was determination of antibodies (igg, igm) against toxoplasma in malignant patientsin order to refer the patients on time to the physician for treatment.methods: this study was carried out on 252 malignant patients and 252 healthy normal subjects (as control) obtained fromshafa hospital and medical diagnostic laboratory (iran-zamin), in ahwaz city. patient’s information was recorded in aquestionnaire before sampling. serum samples of patients were examined for igg and igm antibodies by elisa techniqueusing trinity kits.results: the results of this study revealed the presence of toxoplasma antibodies in 114 (45.2%) cases of patients whowere positive for toxoplasma igg antibodies, and 26 (10.3%) cases were confirmed to be positive for toxoplasma igmantibodies and also 17 (6.7%) of cases had both igg and igm antibodies against toxoplasma gondii. in control group 92(36.5%) cases and 15 (6%) cases revealed seropositive for igg and igm antibodies, respectively. there were no significantdifferences between sex, close contact with cat, living region, chemotherapy, and seropositivity rate of toxoplasmosis inpatients. comparing the age groups, the highest seropositive rate showed in the age of 51 years or higher, and their rates hadtendency to increase with age in both groups. no seropositivity significant relationship was found between patients andcontrol group.conclusion: according to the prevalence of positive cases in these patients, it is necessary to examine the patients fortoxoplasmosis before, during and after chemotherapy.