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comparison between combination therapy of oral terbinafine and cryotherapy versus systemic meglumine antimoniate and cryotherapy in cutaneous leishmaniasis: a randomized clinical trial.
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نویسنده
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farajzadeh saeedeh ,esfandiarpour iraj ,haghdoost ali akbar ,mohammadi saman ,mohebbi azadeh ,mohebbi elham ,mostafavi mahshid
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منبع
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iranian journal of parasitology - 2015 - دوره : 10 - شماره : 1 - صفحه:1 -8
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چکیده
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background: leishmaniasis is a parasitic infection that may lead to a variety of manifestations. in iran, cutaneous leishmaniasis (cl) has a high prevalence. there are many treatment modalities for cl. the use of oral terbinafine in the treatment of cl has recently been considered. the aim of this study was to compare combination of oral terbinafine plus cryotherapy versus systemic me-glumine antimoniate plus cryotherapy in cl. methods:patients with proven direct smear for cl were divided randomly in 2 groups of 40 cases. for the first group systemic glucantime prescribed (im, 15 mg/kg/day) for 3 weeks. for the second group oral terbinafine as two folds of usual dose in the treatment of fungal diseases prescribed [125 mg/day for body weight (bw) <20 kg, 250 mg/day for bw 20-40 kg, 500 mg/day for bw>40 kg] for 4 weeks. both groups received cryotherapy every 2 weeks for 4 weeks. the patients were followed monthly for 3 months after the treatment. results:partial (hr= 0.55, ci 95%= 0.3-1.1) and complete (hr= 0.53, ci 95%= 0.3-0.98) clinical improvement in terbinafine group was much slower than glucantime group, although at the end of treatment protocols no signifi-cant difference between groups were statistically observed (p=0.27). conclusion:considering more convenient suitable route of administration and approximately comparable results, it seems that terbinafine can be used as an alternative treatment, especially in the case of allergy or resistance to systemic glucantime. |
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کلیدواژه
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cryotherapy ,iran ,leishmaniasis ,oral terbinafine ,systemic glucantime
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آدرس
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kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of, kerman university of medical sciences, Iran, Islamic Republic of
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پست الکترونیکی
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ms_mostafavi@yahoo.com
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Authors
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