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interleukin-18 antagonism improved histopathological condi tions of malaria infection in mice
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نویسنده
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jabbarzare marzieh ,chin voon kin ,talib herni ,yam mun fei ,adam siti khadijah ,hassan haniza ,abdul majid roslaini ,mat taib che norma ,mohd moklas mohamad aris ,taufik hidayat mohamad ,mohd sidek hasidah ,basir rusliza
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منبع
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iranian journal of parasitology - 2015 - دوره : 10 - شماره : 3 - صفحه:389 -401
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چکیده
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background: interleukin 18 (il-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. previous studies have demonstrated the promising therapeutic potential of modulating il-18 bioactivity in various pathological conditions. however, its involvement during malaria infection has yet to be established. in this study, we demonstrated the effect of modulating il-18 on the histopathological conditions of malaria infected mice. methods: plasmodium berghei anka infection in male icr mice was used as a model for malaria infection. modulation of il-18 release was carried out by treatment of malarial mice with recombinant mouse il-18 (rmil-18) and recombinant mouse il-18 fc chimera (rmil-18fc) intravenously. histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney. results: treatment with rmil-18fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice. conclusion: il-18 is an important mediator of malaria pathogenesis and targeting il-18 could prove beneficial in malaria-infected host.
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کلیدواژه
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malaria ,interleukin-18 ,plasmodium berghei ,histopathology
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آدرس
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Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, school of pharmaceutical sciences, universiti sains malaysia, penang, malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia, Universiti Kebangsaan Malaysia, Malaysia, Universiti Putra Malaysia, Malaysia
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پست الکترونیکی
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rusliza@upm.edu.my
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Authors
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