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Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice
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نویسنده
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neitzke-abreu herintha coeto ,caetano rhuan carlos souza ,reinhold-castro kárin rosi ,lima-junior manoel sebastião da costa ,santos wagner josé tenório dos ,de melo gessilda de alcantara nogueira ,cuman roberto kenji nakamura ,aristides sandra mara alessi ,silveira thais gomes verzignassi ,lonardoni maria valdrinez campana
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منبع
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iranian journal of parasitology - 2021 - دوره : 16 - شماره : 4 - صفحه:567 -575
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چکیده
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Background: we aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the leishmania (viannia) braziliensis, l. (leishmania) amazonensis, and l. (leishmania) major species in the mesenteric microcirculation of balb/c mice. methods: five experimental groups were considered: group 1 (l. braziliensis); group 2 (l. amazonensis); group 3 (l. major); group 4 (control group with pbs); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. results: infections by the different leishmania species caused an increase in the number of rolling leukocytes: l. braziliensis a peak at 6 h; l. amazonensis and l. major a peak at 3 h. the leishmania infections induced leukocyte adhesion: l. major and l. amazonensis showed an increase after 3 and 6 h, respectively. conclusion: the kinetics of cellular recruitment in leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to leishmania infection and determine its course.
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کلیدواژه
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Leishmania; Rolling; Cellular adhesion; Leukocyte
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آدرس
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universidade estadual de maringá, postgraduate program of health sciences, Brazil. universidade federal da grande dourados, postgraduate program of health sciences, Brazil, universidade estadual de maringá, departament of clinical analysis and biomedicine, Brazil, universidade estadual de maringá, postgraduate program of health sciences, Brazil, oswaldo cruz foundation (fiocruz), aggeu magalhães institute, department of immunology, Brazil, oswaldo cruz foundation (fiocruz), aggeu magalhães institute, department of immunology, Brazil, universidade estadual de maringá, departament of clinical analysis and biomedicine, postgraduate program of biosciences and pathophysiology, Brazil, universidade estadual de maringá, postgraduate program of health sciences, postgraduate program of pharmaceutical sciences, Brazil, universidade estadual de maringá, departament of clinical analysis and biomedicine, postgraduate program of health sciences, Brazil, universidade estadual de maringá, departament of clinical analysis and biomedicine, postgraduate program of health sciences, Brazil, universidade estadual de maringá, departament of clinical analysis and biomedicine, postgraduate program of health sciences, postgraduate program of biosciences and pathophysiology, Brazil
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Authors
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