Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity

Background: adenosine deaminase (ada) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxy-adenosine to inosine and deoxyinosine. ada enzyme deficiency results in the loss of functional properties of b and t lymphocytes. demodex species have been reported to be transmitted between humans through close contact and to play a role in the path-ogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micro-papillary-pruritic dermatitis and blepharitis. the present study aimed to compare se-rum ada levels in d. folliculorum positive patients with the healthy control individu-als. methods: serum ada levels were examined for 30 patients diagnosed with ery-thematotelangiectatic rosacea and 40 healthy individuals in malatya inonu university in 2017. standardized skin surface biopsy (sssb) method was used to diagnose d. folliculorum. a significant decrease was found in the ada levels of demodex-positive rosacea patients when compared to the control group. results: ada levels were decreased in the demodex-positive group. the mean ada level in patient group was significantly lower than the mean in the control group (p<0.001). there was no significant difference between the patient and control groups in terms of age and gender. conclusion: during and after treatment of demodex-positive rosacea patients, de-termination of ada levels may give more detailed information on the immune mechanisms.