Trypanocidal Effects of Cisplatin Alone and in Combination With Nigella Sativa Oil on Experimentally Infected Mice With Trypanosoma Evansi

Background: due to the limited number of the available drugs for the treatment of trypanosomiasis, this study was designed to evaluate the trypanocidal effects of cisplatin or/and nigella sativa oil (nso) in experimentally infected mice with t. evansi. methods: during 2015 at the parasitology department, menoufia university, menoufia, egypt, sixty swiss albino mice were divided into six groups: normal control (i), infected control (ii); cisplatin-treated (iii); nso-treated (iv); combined cisplatin + nso-treated (v) and diminazene-treated (vi). the tested drugs were evaluated by the assessment of parasitaemia, measurement of aspartate aminotransferase (ast), alanine aminotransferase (alt), urea, creatinine, serum igm and a histopathological study. results: nso showed a trypanocidal effect, however; it was not as effective as cisplatin or diminazene. there were significant increases of ast, alt, urea, and creatinine in group ii and iii, which were significantly reduced in cisplatin + nso-treated group (v). moreover, there were significant reductions in serum igm and the pathological changes of the examined organs of group v when they were compared with other treated groups. conclusion: cisplatin combined with nso showed a trypanocidal effect against t. evansi with preservation of vital organs functions and architecture.