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Effect of omega-3 supplementation on lipocalin 2 and retinol-binding protein 4 in type 2 diabetic patients
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نویسنده
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farahbakhsh-farsi p. ,djazayery a. ,eshraghian m.r. ,koohdani f. ,zarei m. ,javanbakht m.h. ,derakhshanian h. ,djalali m.
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منبع
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iranian journal of public health - 2016 - دوره : 45 - شماره : 2 - صفحه:179 -185
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چکیده
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Background: serum levels of lipocalin 2 (lcn 2) and retinol-binding protein-4 (rbp 4),increase in type 2 diabetes mellitus (t2dm). we sought to determine whether serum lcn 2 and rbp 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. methods: forty-five type 2 diabetic patients from iranian diabetic association in tehran,iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. blood samples,food intake records,anthropometric measurements were obtained from all participants at the beginning and end of the study. results: fasting rbp 4 plasma levels significantly changed after 10 wk supplementation (p = 0.01). the lcn 2 concentrations decreased in omega-3 group,but the changes were not statistically significant. omega-3 supplementation had no noticeable effect on anthropometric factors. conclusions: these findings provide a rationale for omega-3 supplements aimed at lowering serum rbp 4 levels in t2dm. © 2016. iranian journal of public health. all right reserved.
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کلیدواژه
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Diabetes mellitus; Lipocalin; Omega-3 fatty acid; Retinol-binding protein
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آدرس
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dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of community nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of biostatistics,school of public health,tehran university of medical sciences,tehran, ایران, dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران, dept. of cellular and molecular nutrition,school of nutritional sciences and dietetics,tehran university of medical sciences,tehran, ایران
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Authors
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